Fractionated lower dose chemotherapy means that we can use chemotherapy on a weekly bases instead of every 3 weeks or full dose chemotherapy that has lots of side effects. In this other way the side effects are much less and the tumor shrinkeage is much faster due to the more often exposure of the malignant cells to the chemo drugs every 8 days. The chemo dosage that we provide goes from 20% to 40% and it will depend from every patient. For example, young patients has better immune system and the time to recover is faster compare with older patients so we can use a higher dose. Also it will depend on the patient sensitivity to these drugs. The final decision will be taken after we do a complete evaluation including blood works and posible PET CT or MRI to have the best idea of the affected organs. As you can see the final decision is totally personalized and it is multifactorial. The chemotherapy protocols are based on the international guidelines known as first line treatments, second or third lines and they are used in all the Oncological hospitals around the world. Guidelines and protocols are designed through the colaboration from Hospitals around the world and the profesionals in the research field, so design and approve a chemotherapy protocol could take more than 10 or 15 years to demosntrate the efficacy and safety. Oncologist are not based in the Chemosensitivity test. We are based on the clinical research and results in the tumor respond, overall survival, etc. Comparative studies takes decades to prove and keep a treatment protocol on use or decide to change it for a new one. There is no other way to achieve the results of a medical treatment.

Cancer cells as the rest of our body cells have insulin receptors. Because cancer cells are highly metabolic they need more expresion of insulin receptors to be able to metabolize glucose much faster than other normal cells and allow them to multiply faster, the only cells that have about the same amount of insulin receptors are brain cells and heart cells. How we can make a 20 or 30 or 40% of chemotherapy dose work much better than regular chemo? It is very important not forget about our metabolism. Trying to induce a Hipoglicemia with insulin using a really low percetage of chemo in a "bolus" can put the patient in risk of metabolic complications because of the insulin amount. Instead of that we need to understand and learn every patient body metabolism and after that we can use medications like metformin to help metabolize the glucose better on a daily bases if the patient really needs it or just playing with a fasting period of 3 to 4 hours before the chemo treatment. In that sense the use of insulin will be really minimum to achieve a safe status of hipoglicemia and nulifing any possible complication in the body for the low glucose period. The chemo delivery protocols like we said are based under the international approved protocols. Most of the times with the combination of 2 drugs, some times 3. Every drug is delivered in a term of 30 minutes to 1 hour and the patient will received a premedication with an antinausea regimen of Zofran and Dexametasone antialergic medication could be required in some special drugs. For patients that are super sensitive for NAUSEA now a day we have newer medications like Palonosetron and Aprepitand that can block the nausea feeling for a period of 5 days in a single IV application even for the strongest chemo regimen on earth. How vectorized insulin works? What is the role? very simple. We impregnate the tumor cells with a little bit of insulin while the chemo is trying to go through the cancer cell membrane most of the time difficult, because the patient is fasting, low in glucose and the cancer cells has that extra "insulin impregnation", means in other words that cancer cells are ready to allow GLUCOSE to be absorved for a metabolism reactivation. When the chemo administration process is finished then a Glucose shot in IV and oral form is delivered in to the blood flow. For instance Cancer cells will allow Glucose molecules to go through the cell membrane and the chemo will take the chance at the same time to penetrate without any resistance and finished with the cancer cell apoptosis or cancer cell death. IMPORTANT. THIS IS NOT IPT. That therapy uses really low dose chemo and higher doses of insulin. We are, AGAIN, BASED on the regular chemo protocols and after 20 years using this modified PROGRAM we can give the next final conclusions: 1.- Patient's tolerance is excellent. 2.- Clinical benefits are visible since the first week. 3.- Possible tumor reduction in 4 to 6 weeks of treatment could be from 30% to 60% and sometimes more in tumors that are very sensitive to chemo like Non Hodgkin Lymphomas, Ovarian cancer platinum sensitive or breast cancer among others. 4.- Response also depends on the patient clincal status and if the patient also received previous chemotherapy. 5.- Hair loss and nausea is not usual problem. Only less than 3% of patients loss hair or developed mild nausea. 6.- Blood cell count affection is possible but now a day we have new medications to repair or produce new cells in term of a few days.

Finally. We are another treatment option for cancer trying to minimize the side effects and improving the results, also protecting the immune system and boosting it. The word 'CURE CANCER' is not in our dictionary. Try to cure cancer is possible but needs at least 5 YEARS of follow up once the cancer is remission to achieve that. It will also depends on the initial cancer stage.